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Idiopathic Premature Ovarian Failure and its association to the abnormal longitudinal changes of telomere length in a population of Iranian Infertile Women: A pilot study

 

Abstract

  • Bachground

The premature ovarian failure (POF) is a reason of infertility that affects about 1–4% of women before age 40. The importance of telomeres length in different diseases has been explored before. This study examines the association between the relative telomere length and idiopathic POF in a group of Iranian women.

  • Methods

The blood genomic DNA was extracted from 40 idiopathic POF patients (case group) and 40 fertile women (control group). The relative telomere length (RTL) was evaluated by quantitative Real-Time PCR using specific telomeric primers. RTL was calculated as T (telomere)/S (single copy gene) ratio and compared between infertile and fertile groups.

  • Results

A strong association was considered between telomere size and idiopathic premature ovarian failure. In patients the relative telomere length showed to be significantly longer than those of control group (P?

  • Conclusion

Our findings demonstrate a possible relationship between telomere lengthening and idiopathic POF. The reason of the observed elevated telomeres genetic material could be explained by numerous probable mechanisms like reduced ovarian cell division rate, a sudden increase in the estrogen level before menopause and after egg depletion, and/or an autoimmune condition which could change the composition of blood cells and their consequent conversion to the cells with longer telomeres in patients. More experiments with larger population are necessary to confirm the results of present study.

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Improvement of oocyte in vitro maturation from mice with polycystic ovary syndrome by human mesenchymal stromal cell–conditioned media

First published: 01 September 2018
 

 

Abstract

The outcome of in vitro maturation (IVM) in the patients with polycystic ovary syndrome (PCOS) is poor. Abnormal intraovarian paracrine interplay alters microenvironment for oocyte development through folliculogenesis and decreases developmental competence of oocytes in patients with PCOS. Mesenchymal stromal cells (MSCs) secrete a variety of cytokines and growth factors that could promote oocyte maturation in vitro. Thus, in the current study we aimed to evaluate the effect of human bone marrow MSC–conditioned media (hBM?MSC?CM), as a supplement, to enrich IVM medium for PCOS germinal vesicles (GVs). For this purpose, oocytes at GV and metaphase II (MII) stages were harvested from PCOS mice. The GVs were randomly divided into four groups and incubated for 24 hours in an IVM medium (TCM199, as the control group) or TCM199 supplemented by 25%, 50%, and 75% of hBM?MSC?CM (PCOS?CM25, PCOS?CM50, and PCOS?CM75 groups, respectively) so as to evaluate which dose(s) could enhance maturation rate of the GVs and their subsequent in vitro fertilization (IVF) outcome. Furthermore, MII oocytes and their subsequent IVF outcome were considered as the in vivo matured (PCOS?IVO) group. The data showed that supplementation of IVM medium with 50% hBM?MSC?CM significantly increased cytoplasmic and nuclear maturation of the GVs (P < 0.001), and also fertilization and two?cell rate (P < 0.001) and blastocyst formation (P < 0.01) of in vitro matured oocytes from mice with PCOS. Overall, higher oocyte maturation and fertilization outcome in PCOS?CM50 group proposed that enrichment of IVM medium with hBM?MSC?CM could be considered as a promising approach to improve IVM of PCOS oocytes.

 

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Epidemiology and Characteristics of Extra-ovarian Conditions Mimicking Ovarian Cancer; A 4-year assay among Iranian women
 
 
Mohammad Hossein Khosravi ; Seyedeh Razieh Hashemi1; Mohammad Ali Hosseini2; Rezvan Ashkesh3; Afsaneh Lalooei1
  1. Obstetrics and Gynecology Department, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
  2. Student research committee, Qazvin university of Medical sciences, Qazvin, Iran 4- Infertility and Reproductive Health Research Center ,Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
  4. Receive Date: 07 May 2018,  Revise Date: 21 September 2018,  Accept Date: 21 September 2018
Abstract
 
Background: Involving approximately 4% of malignancies in women, ovarian cancer remains as one of the most fatal cancers. It is important to consider conditions which are not primary ovarian diseases but mimic their behaviors. So in the present study we aimed to evaluate epidemiological characteristics of extra-ovarian conditions mimicking ovarian masses.
Method: This cross-sectional study was conducted on patients with primary diagnosis of ovarian masses who underwent surgery by gynecologists between January 2012 and March 2016. Primary diagnosis by surgeon and the final histopathology assessment report were evaluated for each patient. In case that the final histopathology report was not in gynecologic spectrum the possible reason of incompatibility was investigated.
Results: Finally 1876 patients with a mean age of 48.26±15.4 years underwent analysis. Among these patients, 27(1.4%) had a kind of non-gynecologic-origin masses. The final diagnoses are divided in four main categories; masses with gastrointestinal-origin (55.5%), infectious (18.5%), those with retroperitoneal-origin (18.5%) and embryologic-origin masses (7.4%).
Conclusion: We concluded that suggest that extra-ovarian diseases should be considered in differential diagnosis of patients with primary diagnosis of ovarian cancer. Also we found that metastases from gastrointestinal tract tumors and infectious diseases are the most common pathologies among extra-ovarian conditions.
 
Keywords
epidemiology; Prevalence; Ovarian cancer; extra-ovarian conditions
 
 

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Affiliation :

Infertility and Reproductive Health 

Research Center , Shahid Beheshti 

University of Medical Sciences, Tehran, Iran

، مرکز تحقیقات بهداشت باروری و ناباروری

، دانشگاه علوم پزشکی شهید بهشتی 

تهران، ایران

پیوندهای مهم

پایگاه اطلاع رسانی مقام معظم رهبری

پایگاه اطلاع رسانی ریاست جمهوری

پایگاه اطلاع رسانی دولت

نهاد نمایندگی مقام معظم رهبری
 
 
مرکز تحقیقات بهداشت باروری و ناباروری دانشگاه علوم پزشکی شهید بهشتی

آدرس : تهران - تجریش - میدان قدس بیمارستان            شهدای تجریش

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پست الکترونیک : irhrc@sbmu.ac.ir

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